Absorption, distribution, metabolism, and, excretion (ADME) are crucial properties to be elucidated during new drug development. Drug metabolism，also known as biotransformation, refers to the process by which a drug undergoes chemical structural changes after it is absorbed and distributed in the body. It is a critical step for elimination of exogenous chemicals from the body. Two major stages, phase I and phase II biotransformation generally occurs. In phase I, hydrolysis, oxidation, and reduction are involved, which allows conjugation process of phase II biotransformation to take place. Liver is enriched with metabolic enzymes and is the major organ and the primary site of biotransformation in the body.
iPhase Biosciences has developed a number of products for drug metabolism studies, including metabolic stability, metabolic phenotype, enzyme inhibition (IC50), liver and intestine microsomes, S9 and cytoplasm of different species, CYPs recombinase, substrates, metabolites, and inhibitors and etc. We also offer customized products for microsomes, S9, cytoplasm, and other unique products collected from animal disease models, and animals at different ages.