What is the role of the positive substrate control? How to detect it?


The positive substrate control is used to indicate the effectiveness of the enzymes in the kit. The positive substrates are well-identified chemicals that are metabolized by microsomal enzymes. The decrease of positive control substance and the increase of its metabolites can be monitored by chromatographic analysis. If the If testing the reduced amount of its prototype drug, it is necessary to properly dilute the positive substrate before performing the test.

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